Th17 cells inhibit CD8+ T cell migration by systematically downregulating CXCR3 expression via IL-17A/STAT3 in advanced-stage colorectal cancer patients

被引：0

作者：

Dan Wang

Weina Yu

Jingyao Lian

Qian Wu

Shasha Liu

Li Yang

Feng Li

Lan Huang

Xinfeng Chen

Zhen Zhang

Aitian Li

Jinbo Liu

Zhenqiang Sun

Junxia Wang

Weitang Yuan

Yi Zhang

机构：

[1] The First Affiliated Hospital of Zhengzhou University,Biotherapy Center

[2] The First Affiliated Hospital of Zhengzhou University,Cancer Center

[3] The First Affiliated Hospital of Zhengzhou University,Department of Anorectal Surgery

[4] The First Affiliated Hospital of Zhengzhou University,Department of Gastrointestinal Surgery

[5] Zhengzhou University,School of Life Sciences

[6] Henan Key Laboratory for Tumor Immunology and Biotherapy,undefined

来源：

Journal of Hematology & Oncology | / 13卷

关键词：

Colorectal cancer; CD8; CXCR3; IL-17A; Th17 cells;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 24 条

[1] Th17 cells inhibit CD8+ T cell migration by systematically downregulating CXCR3 expression via IL-17A/STAT3 in advanced-stage colorectal cancer patients
Wang, Dan
Yu, Weina
Lian, Jingyao
Wu, Qian
Liu, Shasha
Yang, Li
Li, Feng
Huang, Lan
Chen, Xinfeng
Zhang, Zhen
Li, Aitian
Liu, Jinbo
Sun, Zhenqiang
Wang, Junxia
Yuan, Weitang
Zhang, Yi
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 13 (01)
[2] Altered Expression of STAT3, RORγt, and IL-17A Proteins and Th17 Cell in Intrahepatic Cholestasis of Pregnancy
Wu, Yu-Xia
Chen, Qian
Chen, Qiu-He
Shan, Dan
Hu, Ya-Yi
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, 2022, 49 (07):
[3] STAT3 in CD8+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis
Yue, Chanyu
Shen, Shudan
Deng, Jiehui
Priceman, Saul J.
Li, Wenzhao
Huang, Austin
Yu, Hua
CANCER IMMUNOLOGY RESEARCH, 2015, 3 (08) : 864 - 870
[4] Ursolic acid inhibits Th17 cell differentiation via STAT3/RORγt pathway and suppresses Schwann cell-mediated Th17 cell migration by reducing CXCL9/10 expression
Xu, Hua
Yu, Ai-Ling
Zhao, Da-Peng
Meng, Guang-Yuan
Wang, Ling
Shan, Min
Hu, Nai-Xia
Liu, Yun-Lin
INNATE IMMUNITY, 2022, 28 (05) : 155 - 163
[5] Th17 cell-derived IL-17A promoted tumor progression via STAT3/NF-κB/Notch1 signaling in non-small cell lung cancer
Wang, Ruirui
Yang, Li
Zhang, Chaoqi
Wang, Ruijie
Zhang, Zhen
He, Qianyi
Chen, Xinfeng
Zhang, Bin
Qin, Zhihai
Wang, Liping
Zhang, Yi
ONCOIMMUNOLOGY, 2018, 7 (11):
[6] Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients
Winter, Dorian
Moser, Julia
Kriehuber, Ernst
Wiesner, Christoph
Knobler, Robert
Trautinger, Franz
Bombosi, Paula
Stingl, Georg
Petzelbauer, Peter
Rot, Antal
Maurer, Dieter
JOURNAL OF IMMUNOLOGY, 2007, 179 (06): : 4272 - 4282
[7] Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling
Zhang, Junli
Li, Sen
Zhao, Yuzhou
Ma, Pengfei
Cao, Yanghui
Liu, Chenyu
Zhang, Xijie
Wang, Wenpeng
Chen, Li
Li, Yin
ANNALS OF TRANSLATIONAL MEDICINE, 2020, 8 (14)
[8] Colorectal Cancer-Derived Foxp3+IL-17+ T Cells Suppress Tumour-Specific CD8+ T Cells
Ma, C.
Dong, X.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2011, 74 (01) : 47 - 51
[9] IL8 derived from macrophages inhibits CD8+T-cell function by downregulating TIM3 expression through IL8-CXCR2 axis in patients with advanced colorectal cancer
Zhao, Chenhui
Wang, Dan
Li, Zhen
Zhang, Zhen
Xu, Yujie
Liu, Jinbo
Lei, Qingyang
Han, Dong
Huo, Yachang
Liu, Shasha
Li, Ling
Zhang, Yi
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 121
[10] CXCR3 expression defines a novel subset of innate CD8+ T cells that enhance immunity against bacterial infection and cancer upon stimulation with IL-15
Oghumu, Steve
Terrazas, Cesar A.
Varikuti, Sanjay
Kimble, Jennifer
Vadia, Stephen
Yu, Lianbo
Seveau, Stephanie
Satoskar, Abhay R.
FASEB JOURNAL, 2015, 29 (03): : 1019 - 1028

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