Cyclin kinase inhibitors in breast cancer: From bench to bedside

被引：3
|
作者：
Torres G. [1 ]
Echavarría I. [1 ]
Lobo M. [1 ]
Márquez-Rodas I. [1 ]
Martin M. [1 ]
机构：
[1] Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, 28007 Madrid
来源：
Current Breast Cancer Reports | 2014年 / 6卷 / 2期
关键词：
Breast cancer; Cdk4; Cdk6; Cell cycle; Cyclin; Cyclin kinase inhibitors; Palbociclib; Targeted therapy;
D O I：
10.1007/s12609-014-0142-3
中图分类号：
学科分类号：
摘要：
A precise knowledge of cell-cycle machinery and its effect on tumorigenesis has led to the development of a large number of anticancer drugs targeting this pathway. In breast cancer research, the promising results of recent clinical trials of novel selective CDK-inhibitors, for example palbociclib, have generated high expectations for this field. This review gathers the results of the most recent clinical trials of CDK inhibitors for breast cancer, and outlines their potential as anticancer therapy. © Springer Science+Business Media 2014.
引用
收藏
页码：79 / 87
页数：8
相关论文
共 50 条
  • [1] CANCER THERAPY BY CYCLIN-DEPENDENT KINASE INHIBITORS (CDKIS): BENCH TO BEDSIDE
    Hassanzadeh, Ali
    Shomali, Navid
    Soltani-Zangbar, Mohammad Sadegh
    Nasiri, Hadi
    Akbari, Morteza
    EXCLI JOURNAL, 2024, 23 : 862 - 882
  • [2] Breast cancer research from bench to bedside
    Minoru Fujimori
    Breast Cancer, 2010, 17 : 79 - 79
  • [3] Breast cancer research from bench to bedside
    Fujimori, Minoru
    BREAST CANCER, 2010, 17 (02) : 79 - 79
  • [4] Aromatase and Breast Cancer: From Bench to Bedside
    Bulun, Serdar
    BIOLOGY OF REPRODUCTION, 2010, : 73 - 73
  • [5] Hereditary breast cancer: from bench to bedside
    De Greve, Jacques
    Sermijn, Erica
    De Brakeleer, Sylvia
    Ren, Zhuo
    Teugels, Erik
    CURRENT OPINION IN ONCOLOGY, 2008, 20 (06) : 605 - 613
  • [6] From Bench to Bedside: Future Potential for the Translation of Prolactin Inhibitors as Breast Cancer Therapeutics
    Charles V. Clevenger
    Jiamao Zheng
    Elizabeth M. Jablonski
    Traci L. Galbaugh
    Feng Fang
    Journal of Mammary Gland Biology and Neoplasia, 2008, 13 : 147 - 156
  • [7] From bench to bedside: Future potential for the translation of prolactin inhibitors as breast cancer therapeutics
    Clevenger, Charles V.
    Zheng, Jiamao
    Jablonski, Elizabeth M.
    Galbaugh, Traci L.
    Fang, Feng
    JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 2008, 13 (01) : 147 - 156
  • [8] Significance of BRAF Kinase Inhibitors for Melanoma Treatment: From Bench to Bedside
    Fujimura, Taku
    Fujisawa, Yasuhiro
    Kambayashi, Yumi
    Aiba, Setsuya
    CANCERS, 2019, 11 (09)
  • [9] Androgen Receptor in Breast Cancer: From Bench to Bedside
    Chen, Mengyao
    Yang, Yunben
    Xu, Kai
    Li, Lili
    Huang, Jian
    Qiu, Fuming
    FRONTIERS IN ENDOCRINOLOGY, 2020, 11
  • [10] Immunological Mechanisms in Breast Cancer - from Bench to Bedside
    Denkert, Carsten
    Schuetz, Florian
    BREAST CARE, 2016, 11 (02) : 93 - 94
12345