Population Pharmacodynamic Modelling of Aspirin- and Ibuprofen-Induced Inhibition of Platelet Aggregation in Healthy Subjects

被引：0
|
作者：
Ying Hong
Fran M. Gengo
Michelle M. Rainka
Vernice E. Bates
Donald E. Mager
机构：
[1] University at Buffalo,Department of Pharmaceutical Sciences
[2] State University of New York,Department of Pharmacy Practice, University at Buffalo
[3] Dent Neurologic Institute,Department of Pharmaceutical Sciences
[4] State University of New York,undefined
[5] University at Buffalo,undefined
[6] State University of New York,undefined
来源：
Clinical Pharmacokinetics | 2008年 / 47卷
关键词：
Aspirin; Ibuprofen; Platelet Aggregation; Naproxen; Antiplatelet Effect;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: The objective of this study was to develop a mechanism-based pharmacodynamic model that characterizes the antiplatelet effects of aspirin (acetylsalicylic acid) and ibuprofen alone and in combination.
引用
收藏
页码：129 / 137
页数：8
相关论文
共 50 条
  • [1] Population pharmacodynamic modelling of aspirin- and ibuprofen-induced inhibition of platelet aggregation in healthy subjects
    Hong, Ying
    Gengo, Fran M.
    Rainka, Michelle M.
    Bates, Vernice E.
    Mager, Donald E.
    [J]. CLINICAL PHARMACOKINETICS, 2008, 47 (02) : 129 - 137
  • [2] Population pharmacodynamic model of aspirin and ibuprofen induced inhibition of platelet aggregation inhealthy volunteers.
    Gengo, F. M.
    Rainka, M. M.
    Bates, V. E.
    Mager, D. E.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2007, 81 : S24 - S24
  • [3] POPULATION PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES OF EPTIFIBATIDE IN THE INHIBITION OF PLATELET AGGREGATION IN HEALTHY CHINESE SUBJECTS
    Li, Qinmei
    Zhang, Hong
    Wu, Min
    Liu, Jingrui
    Li, Cuiyun
    Ding, Yanhua
    [J]. DRUG METABOLISM AND PHARMACOKINETICS, 2020, 35 (01) : S83 - S84
  • [4] Inhibition of platelet aggregation by aspirin in vitro varies considerably between healthy subjects
    Goodman, Timothy
    Sharma, Pankaj
    Ferro, Albert
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 65 (06) : 988 - 988
  • [5] Effects of ibuprofen on the time course of aspirin-induced inhibition of platelet aggregation.
    Gengo, F.
    Rubin, L.
    Robson, M.
    Gengo, M.
    Rainka, M.
    Bates, V.
    [J]. JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 46 (09): : 1073 - 1073
  • [6] Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects
    Jakubowski, Joseph A.
    Payne, Christopher D.
    Weerakkody, Govinda J.
    Brandt, John T.
    Farid, Nagy A.
    Li, Ying G.
    Naganuma, Hideo
    Lachno, D. Richard
    Winters, Kenneth J.
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2007, 49 (03) : 167 - 173
  • [7] PLATELET VOLUME AND ASPIRIN-INDUCED INHIBITION OF AGGREGATION
    OBRIEN, JR
    JAMIESON, S
    [J]. BLOOD, 1976, 48 (04) : 623 - 624
  • [8] Lack of effect of enteric coating on aspirin-induced inhibition of platelet aggregation in healthy volunteers
    Karha, Juhana
    Rajagopal, Vivek
    Kottke-Marchant, Kandice
    Bhatt, Deepak L.
    [J]. AMERICAN HEART JOURNAL, 2006, 151 (05) : 976.e7 - 976.e11
  • [9] Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol
    Pütter, M
    Grotemeyer, KHM
    Würthwein, G
    Araghi-Niknam, M
    Watson, RR
    Hosseini, S
    Rohdewald, P
    [J]. THROMBOSIS RESEARCH, 1999, 95 (04) : 155 - 161
  • [10] INHIBITION OF COLLAGEN-INDUCED PLATELET-AGGREGATION BY ASPIRIN
    GORDON, JL
    MACINTYRE, DE
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1974, 50 (03) : P469 - P469
12345