Linking class-switch recombination with somatic hypermutation

被引：0
|
作者：
Kazuo Kinoshita
Tasuku Honjo
机构：
[1] Graduate School of Medicine,Department of Medical Chemistry and Molecular Biology
[2] Kyoto University,undefined
[3] Yoshida Konoe-cho,undefined
来源：
Nature Reviews Molecular Cell Biology | 2001年 / 2卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The discovery of activation-induced cytidine deaminase (AID) has revealed that there is a molecular link between two apparently different genetic alteration events — class-switch recombination and somatic hypermutation — which take place in the immunoglobulin loci of antigen-stimulated B lymphocytes. These findings led us to propose that the recognition and cleavage steps of the two events may be mediated by a similar or the same molecule. Because AID seems to be an RNA-editing enzyme, these results also suggest that the complexity of mammalian genetic information may be enriched by an interplay between RNA editing and DNA modification.
引用
收藏
页码：493 / 503
页数：10
相关论文
共 50 条
  • [1] Linking class-switch recombination with somatic hypermutation
    Kinoshita, K
    Honjo, T
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (07) : 493 - 503
  • [2] Separate domains of AID are required for somatic hypermutation and class-switch recombination
    Shinkura, R
    Ito, S
    Begum, NA
    Nagaoka, H
    Muramatsu, M
    Kinoshita, K
    Sakakibara, Y
    Hijikata, H
    Honjo, T
    [J]. NATURE IMMUNOLOGY, 2004, 5 (07) : 707 - 712
  • [3] Separate domains of AID are required for somatic hypermutation and class-switch recombination
    Reiko Shinkura
    Satomi Ito
    Nasim A Begum
    Hitoshi Nagaoka
    Masamichi Muramatsu
    Kazuo Kinoshita
    Yoshimasa Sakakibara
    Hiroko Hijikata
    Tasuku Honjo
    [J]. Nature Immunology, 2004, 5 : 707 - 712
  • [4] Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch Recombination
    Kumar, Anjani
    Priya, Anshu
    Ahmed, Tanzeel
    Grundstrom, Christine
    Negi, Neema
    Grundstrom, Thomas
    [J]. JOURNAL OF IMMUNOLOGY, 2018, 200 (12): : 4146 - 4156
  • [5] Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1–mutant mice
    Philip D Bardwell
    Caroline J Woo
    Kaichun Wei
    Ziqiang Li
    Alberto Martin
    Stephen Z Sack
    Tchaiko Parris
    Winfried Edelmann
    Matthew D Scharff
    [J]. Nature Immunology, 2004, 5 : 224 - 229
  • [6] Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
    Roa, Sergio
    Avdievich, Elena
    Peled, Jonathan U.
    MacCarthy, Thomas
    Werling, Uwe
    Kuang, Fei Li
    Kan, Rui
    Zhao, Chunfang
    Bergman, Aviv
    Cohen, Paula E.
    Edelmann, Winfried
    Scharff, Matthew D.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (42) : 16248 - 16253
  • [7] AID in somatic hypermutation and class switch recombination
    Longerich, S
    Basu, U
    Alt, F
    Storb, U
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2006, 18 (02) : 164 - 174
  • [8] Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice
    Bardwell, PD
    Woo, CJ
    Wei, KC
    Li, ZQ
    Martin, A
    Sack, SZ
    Parris, T
    Edelmann, W
    Scharff, MD
    [J]. NATURE IMMUNOLOGY, 2004, 5 (02) : 224 - 229
  • [9] Activation-induced cytidine deaminase: a dual role in class-switch recombination and somatic hypermutation
    Durandy, A
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2003, 33 (08) : 2069 - 2073
  • [10] Sirt1-mediated metabolic modulation of Aicda, class-switch DNA recombination and somatic hypermutation
    Gan, Huoqun
    Shen, Tian
    Sanchez, Helia
    Xu, Zhenming
    Zan, Hong
    Casali, Paolo
    [J]. JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
12345