Management of IBD in the Elderly Patient With Cancer

被引：2
|
作者：
Garrett Lawlor
Seymour Katz
机构：
[1] Columbia University Medical Center,Inflammatory Bowel Disease Program
[2] New York University School of Medicine,undefined
[3] New York University Langone Medical Center,undefined
来源：
Current Treatment Options in Gastroenterology | 2015年 / 13卷 / 3期
关键词：
Crohn’s; Ulcerative colitis; Cancer; Elderly; Inflammatory bowel disease;
D O I：
10.1007/s11938-015-0061-z
中图分类号：
学科分类号：
摘要：
The management of inflammatory bowel disease (IBD) in patients with known or recently treated cancer has become a common dilemma in our ageing population. Older patients are commonly excluded from prospective trials, and co-morbid status and polypharmacy may muddy our understanding of the impact of therapies on these patients. Immunosuppression (anti-TNF therapy, antimetabolite therapy) carries a relative contra-indication in the setting of known cancer as it is expected to increase cancer risk and increase propagation of in situ cancer. Recent studies have sought to investigate this risk by looking from two sides—the impact of cancer therapies on IBD outcomes and the risk of cancer occurrence/recurrence in patients on IBD therapies. In this chapter, we review this data and determine the safety of commonly used IBD therapies in this potentially vulnerable elderly population.
引用
收藏
页码：301 / 307
页数：6
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