Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

被引：0
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作者：
Gang Chen
Hua Qian
Thomas Starzl
Hongtao Sun
Bertha Garcia
Ximo Wang
Yishai Wise
Yuanqing Liu
Ying Xiang
Laura Copeman
Weihua Liu
Anthony Jevnikar
William Wall
David K C Cooper
Noriko Murase
Yifan Dai
Wanyu Wang
Yuliang Xiong
David J White
Robert Zhong
机构：
[1] University of Western Ontario,Department of Surgery
[2] Thomas E. Starzl Transplantation Institute,Department of Pathology
[3] University of Pittsburgh Medical Center,Department of Medicine
[4] University of Western Ontario,Department of Microbiology and Immunology
[5] Transplantation Group,Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College
[6] Robarts Research Institute,undefined
[7] University of Western Ontario,undefined
[8] Transplantation and Regenerative Medicine,undefined
[9] Lawson Health Research Institute,undefined
[10] Multi-Organ Transplant Program,undefined
[11] London Health Sciences Centre,undefined
[12] Revivicor,undefined
[13] Inc.,undefined
[14] Animal Toxicological Laboratory,undefined
[15] Kunming Institute of Zoology,undefined
[16] Chinese Academy of Science,undefined
[17] University of Western Ontario,undefined
[18] Huazhong University of Science and Technology,undefined
来源：
Nature Medicine | 2005年 / 11卷
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摘要：
We transplanted kidneys from α1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans.
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页码：1295 / 1298
页数：3
相关论文
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