A retrospective study on 687 canine ehrlichiosis cases was carried out during January 2001-December 2003 at the Chulalongkorn Small Animal Teaching Hospital, Faculty of Veterinary Science, Chulalongkorn University. Data on rectal temperature, clinical hematology, and biochemistry were analyzed on the first day of admission. The incidences each year were observed in December 2001 (24 cases), June and July 2002 (31 cases each), and October 2003 (38 cases). The clinical findings varied, although most cases showed a high fever (33%), severe anemia (18%), leukocytosis (18%) or leukopenia (19%), thrombocytopenia (93%), and hepatic enzyme elevation. It followed that the therapeutic plan should comprise both specific and clinically supportive treatments, including hematotonics hepatotonics. © Springer-Verlag London Limited 2005.