Automation of X-ray crystallography

被引:0
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作者
Enrique Abola
Peter Kuhn
Thomas Earnest
Raymond C. Stevens
机构
[1] The Scripps Research Institute,Department of Molecular Biology
[2] Syrrx Inc.,Physical Biosciences Division
[3] Stanford Synchrotron Radiation Laboratory,undefined
[4] Stanford University,undefined
[5] Berkeley Center for Structural Biology,undefined
[6] MS6-2100,undefined
[7] Lawrence Berkeley National Laboratory,undefined
[8] The Genomics Institute for the Novartis Research Foundation ,undefined
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摘要
Structure-based biological discovery is entering a new era with the development of industrialized macromolecular structure determination pipelines. Intense, highly focused X-rays from integrated synchrotron radiation beam lines combined with significant advances in protein expression, purification, and micro-crystallization automation allow for the full streamlining of the traditionally tedious and time consuming process of determining the three dimensional structures of macromolecules.
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页码:973 / 977
页数:4
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