Structure-based biological discovery is entering a new era with the development of industrialized macromolecular structure determination pipelines. Intense, highly focused X-rays from integrated synchrotron radiation beam lines combined with significant advances in protein expression, purification, and micro-crystallization automation allow for the full streamlining of the traditionally tedious and time consuming process of determining the three dimensional structures of macromolecules.
机构:
Hungarian Acad Sci, Inst Organ Chem, Res Ctr Nat Sci, Res Grp Chem Crystallog, H-1051 Budapest, HungaryHungarian Acad Sci, Inst Organ Chem, Res Ctr Nat Sci, Res Grp Chem Crystallog, H-1051 Budapest, Hungary
机构:
Univ Lorraine, CRM2, UMR 7036, F-54506 Vandoeuvre Les Nancy, France
CNRS, UMR 7036, CRM2, F-54506 Vandoeuvre Les Nancy, FranceUniv Lorraine, CRM2, UMR 7036, F-54506 Vandoeuvre Les Nancy, France