Microwave-Assisted Synthesis and Evaluation of Bis[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] 7,8′-Methylenebis[2-(E)-(benzylideneamino)-4H-chromene-3-carboxylates] as Potent Antimicrobial Agents

被引：0

作者：

Srinivas, A. ^{[1
]}

Rajitha, S. ^{[2
]}

Rao, E. Kalyan ^{[3
]}

Sindhura, K. ^{[4
]}

Farheen, S. I. ^{[4
]}

Chandrakala, G. ^{[4
]}

Sultana, S. ^{[5
]}

机构：

[1] Vaagdevi Degree & PG Coll, Dept Chem, Hanamkonda 506001, Telangana, India

[2] Career Point Univ, Sch Sci, Kota 325003, Rajasthan, India

[3] Kakatiya Inst Technol Sci, Dept Phys Sci, Hanamkonda 506009, Telangana, India

[4] Vaagdevi Degree & PG Coll, Dept Microbiol, Warangal 506001, Telangana, India

[5] Vaagdevi Degree & PG Coll, Dept Humanities, Warangal 506001, Telangana, India

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 01期

关键词：

methylenebisheterocycles; Knoevenagel condensation; click reaction; glucose; microwave-assisted synthesis; antimicrobial activity; CLICK CHEMISTRY; IN-VITRO; HYBRID HETEROCYCLICS; ACETYLCHOLINESTERASE; DERIVATIVES; INHIBITORS; DISCOVERY; TRIAZOLE; DESIGN; SITU;

D O I：

10.1134/S1070428024010123

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel bis[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl] 7,8 '-methylenebis[2-(E)-(benzylideneamino)-4H-chromene-3-carboxylates] 6a-6f were synthesized from di(prop-2-yn-1-yl) 7,8 '-methylenebis[(E)-2-(benzylideneamino)-4H-chromene-3-carboxylates] 5a-5f via a one-pot procedure involving 1,3-dipolar cycloaddition catalyzed by CuSO4 and glucose under microwave irradiation at 100 degrees C as a key step. Compounds 6d and 6f bearing 4-NO2 and 4-OH groups exhibited good activity against some fungal strains, and compounds 6b and 6f bearing 4-Cl and 4-OH groups exhibited good antimicrobial activity against S.pyogenes, E.coli, B.subtilis, and S.aureus.

引用

页码：84 / 92

页数：9

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