The Integrative Human Microbiome Project

被引：0

作者：

机构：

[1] National Institutes of Health,National Human Genome Research Institute

[2] University of Maryland School of Medicine,Institute for Genome Sciences

[3] School of Medicine,Department of Microbiology and Immunology

[4] Virginia Commonwealth University,Department of Obstetrics and Gynecology, School of Medicine

[5] Virginia Commonwealth University,Center for Microbiome Engineering and Data Analysis

[6] Virginia Commonwealth University,Department of Biostatistics

[7] Harvard T.H. Chan School of Public Health,Department of Genetics

[8] Broad Institute of MIT and Harvard,Department of Computer Science, College of Engineering

[9] Stanford University School of Medicine,Department of Immunology and Infectious Diseases

[10] Virginia Commonwealth University,undefined

[11] Stanford Center for Genomics and Personalized Medicine,undefined

[12] Stanford Diabetes Research Center,undefined

[13] The Jackson Laboratory for Genomic Medicine,undefined

[14] Harvard T.H. Chan School of Public Health,undefined

来源：

Nature | 2019年 / 569卷

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摘要：

The NIH Human Microbiome Project (HMP) has been carried out over ten years and two phases to provide resources, methods, and discoveries that link interactions between humans and their microbiomes to health-related outcomes. The recently completed second phase, the Integrative Human Microbiome Project, comprised studies of dynamic changes in the microbiome and host under three conditions: pregnancy and preterm birth; inflammatory bowel diseases; and stressors that affect individuals with prediabetes. The associated research begins to elucidate mechanisms of host–microbiome interactions under these conditions, provides unique data resources (at the HMP Data Coordination Center), and represents a paradigm for future multi-omic studies of the human microbiome.

引用

页码：641 / 648

页数：7

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