A Solution and Solid State Study on 2-Hydroxypropyl-β-Cyclodextrin Complexation with Hyodeoxycholic Acid

被引：0
|
作者：
M. A. Vandelli
B. Ruozi
F. Forni
A. Mucci
G. Salvioli
E. Galli
机构：
[1] University of Modena e Reggio Emilia,Department of Pharmaceutical Sciences
[2] University of Modena e Reggio Emilia,Department of Chemistry
[3] University of Modena e Reggio Emilia,Department of Medicine
[4] University of Modena and Reggio Emilia,Department of Earth Sciences
来源：
Journal of inclusion phenomena and macrocyclic chemistry | 2000年 / 37卷
关键词：
hyodeoxycholic acid; 2-Hydroxypropyl-β-cyclodextrin; Inclusion complex; Solubility studies; C- and ; H-NMR spectroscopy; Circular dichroism; IR spectroscopy; X-ray diffractometry; Thermal analysis; Dissolution;
D O I：
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中图分类号：
学科分类号：
摘要：
Hyodeoxycholic acid (HDCA) isa 6-α dihydroxylated natural bile acid capable ofpreventing gallstone formation by reducing the bilecholesterol saturation. However, any attempt to enrichthe bile acid pool with HDCA have failed owing to thepoor solubility of the molecule. To resolve thebioavailability problems, the complexation of HDCAinto the HPβCD cavity was studied in solution(solubility methods, 13C- and 1H-NMRspectroscopy and circular dichroism) and in the solidstate (IR spectroscopy, X-ray diffractometry andthermal analysis). According to the results, the HDCAinclusion took place with 1 : 1 stoichiometry. Theinfluence of different preparation methods of thesolid complex was evaluated for its potential use inappropriate pharmaceutical formulations to improve thebioavailability of HDCA.
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页码：237 / 251
页数：14
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