Personalized participatory medicine: sharing knowledge and uncertainty

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作者
David Gurwitz
Jeantine E Lunshof
机构
[1] Sackler Faculty of Medicine,Department of Human Molecular Genetics and Biochemistry
[2] Tel-Aviv University,Faculty of Health, Medicine and Life Sciences
[3] Maastricht University,Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences
[4] VU University Amsterdam and Netherlands Institute for Systems Biology (NISB),Ethics Consultant, Center for Excellence in Genomic Science and Personal Genome Project, Department of Genetics
[5] Harvard Medical School,undefined
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Tamoxifen; Personalized Medicine; Breast Cancer Recurrence; Alternative Treatment Option; Personal Genome;
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摘要
Informing patients about risks and benefits of alternative treatment options and choosing between them is becoming a bigger challenge as knowledge about the relationship between the individual's genetic profile and the efficacy and safety of available medications accumulates. Putting personalized medicine into practice requires new modes of information sharing and decision making by patient and physician. This is illustrated by a case study on treatment choices of breast cancer patients following genotyping for CYP2D6, recently published in Genome Medicine.
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