N-in-One Permeability Studies of Heterogeneous Sets of Compounds Across Caco-2 Cell Monolayers

被引：0
|
作者：
Leena Laitinen
Heli Kangas
Ann Marie Kaukonen
Kati Hakala
Tapio Kotiaho
Risto Kostiainen
Jouni Hirvonen
机构：
[1] University of Helsinki,Viikki Drug Discovery Technology Center (DDTC), Department of Pharmacy
[2] University of Helsinki,Division of Biopharmaceutics and Pharmacokinetics
[3] University of Helsinki,Division of Pharmaceutical Chemistry
来源：
Pharmaceutical Research | 2003年 / 20卷
关键词：
Caco-2 monolayers; permeability; n-in-one cocktails; LC-ESI/MS/MS analysis; increased throughput;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. The purpose of the study was to evaluate several n-in-one cocktails of heterogeneous compounds to increase the throughput of permeability studies across Caco-2 monolayers, to investigate the reliability and applicability of the method, and to develop fast and sensitive analysis for the compounds. Compounds with potential interactions in efflux and/or active transport were chosen.
引用
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页码：187 / 197
页数：10
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