AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation

被引：0
|
作者：
Johanna T Lanner
Dimitra K Georgiou
Adan Dagnino-Acosta
Alina Ainbinder
Qing Cheng
Aditya D Joshi
Zanwen Chen
Viktor Yarotskyy
Joshua M Oakes
Chang Seok Lee
Tanner O Monroe
Arturo Santillan
Keke Dong
Laurie Goodyear
Iskander I Ismailov
George G Rodney
Robert T Dirksen
Susan L Hamilton
机构：
[1] Department of Molecular Physiology and Biophysics Baylor College of Medicine,
[2] Department of Pharmacology and Physiology University of Rochester Medical Center,undefined
[3] Joslin Diabetes Center Research Division,undefined
来源：
Nature Medicine | 2012年 / 18卷
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摘要：
Mutations in the type I ryanodine receptor (RYR1), a calcium channel, leads to stimulus-induced pathological muscle contractions, including malignant hyperthermia. Currently there are no pharmacological agents to protect against this condition, but Susan Hamilton and her colleagues have now identified AICAR as one possible candidate compound. To date, AICAR has been thought to be an AMPK activator, but her group shows that in a mouse model of malignant hyperthermia it does not target this kinase, but rather RYR1, to prevent improper calcium leakage and pathology.
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页码：244 / 251
页数：7
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