Synthesis and pharmacological evaluation of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione

被引：0
|
作者：
Jerzy Kossakowski
Anna Bielenica
Marta Struga
Anna E. Koziol
机构：
[1] The Medical University of Warsaw,Department of Medical Chemistry
[2] Maria Curie-Sklodowska University,Faculty of Chemistry
来源：
Medicinal Chemistry Research | 2008年 / 17卷
关键词：
Cyclic imide derivative; N-phenylpiperazine derivative; 5HT; and 5HT; receptor affinity;
D O I：
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中图分类号：
学科分类号：
摘要：
The synthesis and pharmacological activity of 4-[2-hydroxy-3-(4-phenyl-piperazin-1-yl)-propoxy]-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione is described. The structure of the compound was confirmed by elemental analysis, 1H nuclear magnetic resonance (NMR), 13C NMR, mass spectra, and X-ray crystallography. The compound exhibited significant affinity to both 5-HT1A and 5-HT2A receptors, similarly to aripiprazole, which is an atypical antipsychotic drug.
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页码：507 / 514
页数：7
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