Translational and clinical implications of the genetic landscape of prostate cancer

被引：0
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作者：
Daniel E. Spratt
Zachary S. Zumsteg
Felix Y. Feng
Scott A. Tomlins
机构：
[1] University of Michigan Medical School,Department of Radiation Oncology
[2] Cedars Sinai Medical Center,Department of Radiation Oncology
[3] Michigan Center for Translational Pathology,Department of Pathology
[4] University of Michigan Medical School,Department of Urology
[5] University of Michigan Medical School,undefined
[6] University of Michigan Medical School,undefined
来源：
Nature Reviews Clinical Oncology | 2016年 / 13卷
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摘要：
Investigations of the genomic landscape of primary and metastatic castration-resistant prostate cancer have provided fundamental insights into the pathogenesis of this diseaseNovel molecular subtypes have been devised based on data from large, high-throughput sequencing efforts that have provided information on the molecular alterations that drive the progression of prostate cancerDNA repair aberrations are found in a substantial percentage of metastatic castration-resistant tumour biopsy samples, and these tumours seem to preferentially respond to PARP inhibitorsTumour heterogeneity is a complex process that continues to be a formidable obstacle to treatment
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页码：597 / 610
页数：13
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