Regioselective synthesis of polyfluoroalkyl-substituted 7-(1H-1,2,3-triazol-1-yl)-6,7-dihydro-1H-indazol-4(5H)-ones

被引：0
|
作者：
T. S. Khlebnikova
Yu. A. Piven’
A. V. Baranovskii
F. A. Lakhvich
机构：
[1] National Academy of Sciences of Belarus,Institute of Bioorganic Chemistry
来源：
Russian Journal of Organic Chemistry | 2012年 / 48卷
关键词：
Cross Peak; Phenylacetylene; Terminal Alkyne; REGIOSELECTIVE Synthesis; Indazolones;
D O I：
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中图分类号：
学科分类号：
摘要：
3-Polyfluoroalkyl-6,6-dimethyl-7-(1H-1,2,3-triazol-1-yl)-6,7-dihydro-1H-indazol-4(5H)-ones were synthesized with high regioselectivity by 1,3-dipolar cycloaddition of terminal alkynes (phenylacetylene, hex- 1-yne, hept-1-yne, and but-3-yn-1-ol) to 7-azido-6,6-dimethyl-3-polyfluoroalkyl-6,7-dihydro-1H-indazol-4(5H)-ones which were prepared by bromination of 6,6-dimethyl-3-polyfluoroalkyl-6,7-dihydro-1H-indazol- 4(5H)-ones with N-bromosuccinimide in anhydrous carbon tetrachloride, followed by treatment of the corresponding 7-bromo derivatives with sodium azide.
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页码：411 / 418
页数：7
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