To study the effect of multi-interventional package (MIP) on self-efficacy and perceived quality of life (QOL) of mothers of children with cerebral palsy (CP) and to identify the association between their self-efficacy and perceived QOL with selected socio-demographic variables. A pre experimental one group pre-test post-test study was conducted over a period of six weeks among 30 mothers of children with CP attending Child Development Services. The study tools were a semi structured interview schedule, self-efficacy assessment scale and WHOQOL-BREF scale. The critical study variables were measured prior to the administration of MIP. After the pre-test, MIP was administered to all subjects. The critical study variables were reassessed six weeks after the intervention. The mean scores for self-efficacy and QOL before MIP were 29.4 ± 6.43 and 43.2 ± 6.8, respectively, whereas after MIP, they were 62 ± 9.5 and 85.9 ± 11.8. (t = 13.2, p =.001; t = 9.99, p =.001). The estimated p value for the association of perceived QOL with selected socio-demographic characteristics of mothers of children with CP was less than 0.05 for type of family, education, economic status, degree of disability of child, frequency of hospitalization and co-morbidity. The results showed a significant improvement in the subject in terms of self-efficacy and perceived QOL after MIP. Significant association was identified for various socio-demographic variables with perceived QOL of mothers of children with CP. © 2022, The Author(s), under exclusive licence to Springer Nature India Private Limited.