Peroxisome proliferator-activated receptor α target genes

被引：0
|
作者：
S. Mandard
M. Müller
S. Kersten
机构：
[1] Wageningen University,Nutrition, Metabolism and Genomics Group
来源：
Cellular and Molecular Life Sciences CMLS | 2004年 / 61卷
关键词：
PPARα; transcriptional regulation; target genes; lipid metabolism; PPAR response element;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic compounds such as long-chain fatty acids and their derivatives on transcription of genes commonly called PPAR target genes. Here we review the involvement of PPARα in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways, through a detailed analysis of the different known or putative PPARα target genes.
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页码：393 / 416
页数：23
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