Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference

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作者
Xiaoting Wang
David A Gallegos
Vladimir M Pogorelov
Justin K O’Hare
Nicole Calakos
William C Wetsel
Anne E West
机构
[1] Duke University Medical Center,Department of Neurobiology
[2] Duke University Medical Center,Department of Psychiatry and Behavioral Sciences
[3] Duke University Medical Center,Department of Neurology
[4] Duke University Medical Center,Department of Cell Biology
来源
Neuropsychopharmacology | 2018年 / 43卷
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摘要
To determine the requirement for parvalbumin (PV) expressing GABAergic interneurons of the nucleus accumbens (NAc) in the behavioral adaptations induced by amphetamine (AMPH), we blocked synaptic vesicle release from these neurons using Cre-inducible viral expression of the tetanus toxin light chain in male and female PV-Cre mice. Silencing PV+ interneurons of the NAc selectively inhibited the expression of locomotor sensitization following repeated injections of AMPH and blocked AMPH-induced conditioned place preference (CPP). AMPH induced significantly more expression of the activity-dependent gene Fos in both D1 and D2 dopamine receptor-expressing medium spiny neurons (MSNs) of the NAc of PV+ interneuron silenced mice, suggesting a function for PV+ interneuron-mediated MSN inhibition in the expression of AMPH-induced locomotor sensitization and CPP. These data show a requirement for PV+ interneurons of the NAc in behavioral responses to AMPH, and they raise the possibility that modulation of PV+ interneuron function may alter the development or expression of psychostimulant-induced behavioral adaptations.
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页码:953 / 963
页数:10
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