Investigation of antibiotic resistance determinants and virulence factors of uropathogenic Escherichia coli

被引：0
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作者：
Ding-he Sun
Ding-feng Lv
Zu-huang Mi
Li-qing Hu
Yi Huang
Xiang Gao
Xing-bei Weng
机构：
[1] Ningbo First Hospital,Department of Laboratory Medicine
[2] Zhejiang University School of Medicine,Department of Laboratory Medicine, Ningbo Hospital
[3] Wuxi Clon-Gen Institute,Department of Bioinformation
[4] Ningbo First Hospital,Department of Neurosurgery
[5] Zhejiang University School of Medicine,Department of Neurosurgery, Ningbo Hospital
来源：
The Journal of Antibiotics | 2020年 / 73卷
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摘要：
Multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) are prevalent throughout the world resulting in a major public health burden. In this research, we isolated and identified 28 MDR UPEC from one university hospital in China, investigated MDR and pathogenic mechanisms by PCR, including 55 antibiotic resistance determinants (ARDs) genes, 13 genetic markers of mobile genetic elements (MGEs) and 6 virulence factors (VFs) genes. In these isolates, we identified 23 ARDs genes and 6 genetic markers of MGEs that played a key role in MDR phenotypes. In addition, we found 2 VFs genes, hofQ and ompT, which could be associated with pathogenicity and invasiveness of these strains in urinary tract infections (UTIs).
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页码：314 / 319
页数：5
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