Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

被引：0

作者：

Sung-Youl Ko

Amarendra Pegu

Rebecca S. Rudicell

Zhi-yong Yang

M. Gordon Joyce

Xuejun Chen

Keyun Wang

Saran Bao

Thomas D. Kraemer

Timo Rath

Ming Zeng

Stephen D. Schmidt

John-Paul Todd

Scott R. Penzak

Kevin O. Saunders

Martha C. Nason

Ashley T. Haase

Srinivas S. Rao

Richard S. Blumberg

John R. Mascola

Gary J. Nabel

机构：

[1] Vaccine Research Center,Division of Gastroenterology, Department of Medicine

[2] National Institute of Allergy and Infectious Diseases,Department of Microbiology

[3] National Institutes of Health,Pharmacy Department

[4] Building 40,Division of Clinical Research

[5] Room 4502,undefined

[6] MSC-3005,undefined

[7] 40 Convent Drive,undefined

[8] Bethesda,undefined

[9] Maryland 20892-3005,undefined

[10] USA,undefined

[11] Brigham & Women’s Hospital,undefined

[12] Harvard Medical School,undefined

[13] 75 Francis Street,undefined

[14] Boston,undefined

[15] Massachusetts 02115,undefined

[16] USA,undefined

[17] Medical School,undefined

[18] University of Minnesota,undefined

[19] 420 Delaware Street South East,undefined

[20] Minneapolis,undefined

[21] Minnesota 55455,undefined

[22] USA,undefined

[23] Clinical Pharmacokinetics Laboratory,undefined

[24] Clinical Center,undefined

[25] National Institutes of Health,undefined

[26] Building 10,undefined

[27] 10 Center Drive,undefined

[28] Biostatistics Research Branch,undefined

[29] National Institute of Allergy and Infectious Diseases,undefined

[30] National Institutes of Health,undefined

[31] 6700A Rockledge Drive,undefined

[32] Room 5235,undefined

[33] Bethesda,undefined

[34] Maryland 20892,undefined

[35] USA,undefined

[36] Present addresses: Sanofi,undefined

[37] 640 Memorial Drive,undefined

[38] Cambridge,undefined

[39] Massachusetts 02139,undefined

[40] USA (R.S.R.,undefined

[41] Z.-Y.Y. and G.J.N.); Center for Genetics of Host Defense,undefined

[42] University of Texas Southwestern Medical Center,undefined

[43] 5323 Harry Hines Boulevard,undefined

[44] Dallas,undefined

[45] Texas 75235-8505,undefined

[46] USA (M.Z.); University of North Texas System College of Pharmacy,undefined

[47] 3500 Camp Bowie Boulevard,undefined

[48] RES-340J,undefined

[49] Fort Worth,undefined

[50] Texas 76107,undefined

来源：

Nature | 2014年 / 514卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A mutation in VRC01, a broadly neutralizing, HIV-1-specific antibody, confers enhanced binding to the neonatal Fc receptor, increasing the antibody half-life in the serum and localization in mucosal tissues, where it provides superior protection against rectal simian HIV-1 infection in macaques.

引用

页码：642 / 645

页数：3

共 50 条

[1] Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
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Schmidt, Stephen D.
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Saunders, Kevin O.
Nason, Martha C.
Haase, Ashley T.
Rao, Srinivas S.
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Mascola, John R.
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[J]. NATURE, 2014, 514 (7524) : 642 - +
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