The chemical and isotope compositions of slab dehydration fluids from convergent margins have been theorized by many authors who have adopted several approaches. A direct collection of natural water is possible only in an oceanic environment, despite several difficulties in estimating the deepest component due to the mixing with seawater or hydrothermal fluids from the ridge. Accordingly, the study of melt inclusions is a valuable alternative. However, the latter mainly represents high temperature/pressure conditions in deep magmatic or metamorphic settings. Here, we present new H, O, Li and B isotope along with a revision of previously published chemical data from a potential natural example of slab dehydration water, sampled in a forearc region and affected by low-temperature metamorphism and serpentinization processes (Aqua de Ney, Northern California). Its extreme composition challenges the understanding of its origin and deep temperature, but this work is a further step on a topic of increasing interest for several scientists from different academic disciplines.