Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo

被引：0

作者：

Alexander Ulges

Matthias Klein

Sebastian Reuter

Bastian Gerlitzki

Markus Hoffmann

Nadine Grebe

Valérie Staudt

Natascha Stergiou

Toszka Bohn

Till-Julius Brühl

Sabine Muth

Hajime Yurugi

Krishnaraj Rajalingam

Iris Bellinghausen

Andrea Tuettenberg

Susanne Hahn

Sonja Reißig

Irma Haben

Frauke Zipp

Ari Waisman

Hans-Christian Probst

Andreas Beilhack

Thierry Buchou

Odile Filhol-Cochet

Brigitte Boldyreff

Minka Breloer

Helmut Jonuleit

Hansjörg Schild

Edgar Schmitt

Tobias Bopp

机构：

[1] Institute for Immunology,Department of Pulmonary Medicine

[2] University Medical Center of the Johannes Gutenberg-University Mainz,Department of Immunology and Virology

[3] III. Medical Clinic of the University Medical Center,Department of Neurology

[4] Johannes Gutenberg-University Mainz,undefined

[5] Dermatology,undefined

[6] University Medical Center of the Johannes Gutenberg-University Mainz,undefined

[7] Institute for Molecular Medicine,undefined

[8] University Medical Center of the Johannes Gutenberg-University Mainz,undefined

[9] Bernhard Nocht Institute for Tropical Medicine,undefined

[10] University Medical Center of the Johannes Gutenberg-University Mainz,undefined

[11] Experimentelle Stammzelltransplantation der Medizinische Klinik und Poliklinik II,undefined

[12] Zentrum für Experimentelle Molekulare Medizin,undefined

[13] Julius-Maximilians-Universität Würzburg,undefined

[14] INSERM,undefined

[15] U823,undefined

[16] Université Joseph Fourier-Grenoble1,undefined

[17] Institut Albert Boniot,undefined

[18] Faculté de Médecine,undefined

[19] Domaine de la Merci,undefined

[20] INSERM U1036,undefined

[21] Institute de Recherches en Technologies et Sciences pour le Vivant/Biologie du Cancer et de l'Infection,undefined

[22] Commissariat à l'Énergie Atomique et aux Énerigies Alternatives Grenoble,undefined

[23] KinaseDetect,undefined

来源：

Nature Immunology | 2015年 / 16卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The mechanisms that control the suppressive function of Treg cells in specific tissues are unclear. Bopp and colleagues show that Treg cells have high expression of kinase CK2 and this is critical for their ability to suppress type 2 responses in the lungs.

引用

页码：267 / 275

页数：8

共 50 条

[1] Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo
Ulges, Alexander
Klein, Matthias
Reuter, Sebastian
Gerlitzki, Bastian
Hoffmann, Markus
Grebe, Nadine
Staudt, Valerie
Stergiou, Natascha
Bohn, Toszka
Bruehl, Till-Julius
Muth, Sabine
Yurugi, Hajime
Rajalingam, Krishnaraj
Bellinghausen, Iris
Tuettenberg, Andrea
Hahn, Susanne
Reissig, Sonja
Haben, Irma
Zipp, Frauke
Waisman, Ari
Probst, Hans-Christian
Beilhack, Andreas
Buchou, Thierry
Filhol-Cochet, Odile
Boldyreff, Brigitte
Breloer, Minka
Jonuleit, Helmut
Schild, Hansjoerg
Schmitt, Edgar
Bopp, Tobias
[J]. NATURE IMMUNOLOGY, 2015, 16 (03) : 267 - U227
[2] REGULATORY T CELLS CK2: keeping TH2 cells in check
Bird, Lucy
[J]. NATURE REVIEWS IMMUNOLOGY, 2015, 15 (03)
[3] It takes CK2 to suppress TH2
Sawant, Deepali V.
Dent, Alexander L.
[J]. NATURE IMMUNOLOGY, 2015, 16 (03) : 224 - 225
[4] It takes CK2 to suppress TH2
Deepali V Sawant
Alexander L Dent
[J]. Nature Immunology, 2015, 16 : 224 - 225
[5] Protein kinase CK2 as an ectokinase:: The role of the regulatory CK2β subunit
Rodriguez, Fernando A.
Contreras, Carlos
Bolanos-Garcia, Victor
Allende, Jorge E.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (15) : 5693 - 5698
[6] CK2: keeping TH2 cells in check
Lucy Bird
[J]. Nature Reviews Immunology, 2015, 15 (3) : 134 - 134
[7] The regulatory β subunit of protein kinase CK2 mediates formation of tetrameric CK2 complexes
Graham, KC
Litchfield, DW
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (07) : 5003 - 5010
[8] Structure of the Human Protein Kinase CK2 Catalytic Subunit CK2α′ and Interaction Thermodynamics with the Regulatory Subunit CK2β
Bischoff, Nils
Olsen, Birgitte
Raaf, Jennifer
Bretner, Maria
Issinger, Olaf-Georg
Niefind, Karsten
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2011, 407 (01) : 1 - 12
[9] Transcriptional coordination of the genes encoding catalytic (CK2α) and regulatory (CK2β) subunits of human protein kinase CK2
Walter Pyerin
Karin Ackermann
[J]. Molecular and Cellular Biochemistry, 2001, 227 : 45 - 57
[10] Transcriptional coordination of the genes encoding catalytic (CK2α) and regulatory (CK2β) subunits of human protein kinase CK2
Pyerin, W
Ackermann, K
[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY, 2001, 227 (1-2) : 45 - 57

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