Protective effects of vitamin E against CCl4-induced hepatotoxicity in rabbits

被引：0
|
作者：
K. Pawłowska-Góral
M. Wardas
P. Wardas
A. Rzepecka-Stojko
机构：
[1] Medical University of Silesia,Department of Food and Nutrition
[2] E. N. T. Clinic of Medical University of Silesia,undefined
来源：
Chemical Papers | 2007年 / 61卷
关键词：
antioxidant enzymes; glutathione; total antioxidant status; malonic dialdehyde; vitamin E;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The influence of CCl4 on the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), the value of the total antioxidant status (TAS), and the concentration of malonic dialdehyde (MDA) and glutathione (GSH) was monitored in plasma or whole blood of rabbits. The administration of CCl4 caused the increase of the SOD activity to approximately 150 % and the decrease in the activity of GPx and GR by about 50 %. These changes were accompanied with the increase in TAS value and MDA concentration and the decrease of GSH concentration. The effect of CCl4 was suppressed by the previous 7 days lasting or simultaneous administration of vitamin E. Oxidative stress caused by CCl4 was accompanied by the development of reactive oxygen forms, especially superoxide radical anion.
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页码：6 / 10
页数：4
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