Pathways of neuron-astrocyte interactions and their possible role in neuroprotection

被引：0

作者：

Frank Kirchhoff

Ralf Dringen

Christian Giaume

机构：

[1] Max Planck Institute of Experimental Medicine,

[2] Neurogenetics,undefined

[3] Hermann-Rein-Str. 3,undefined

[4] 37075 Göttingen,undefined

[5] Germany,undefined

[6] Tel.: +49-5 51/38 99-7 10,undefined

[7] Fax: +49-5 51/38 99-7 58,undefined

[8] E-Mail: kirchhoff@em.mpg.de,undefined

[9] Institute for Physiological Chemistry,undefined

[10] University of Tübingen,undefined

[11] Hoppe-Seyler-Strasse 4,undefined

[12] 72076 Tübingen,undefined

[13] Germany,undefined

[14] Tel.: +49-70 71/2 97 33 34,undefined

[15] Fax: +49-70 71/29 53 60,undefined

[16] E-Mail: ralf.dringen@uni-tuebingen.de,undefined

[17] INSERM U114,undefined

[18] College de France 11,undefined

[19] 75231 Paris Cedex 05,undefined

[20] France,undefined

[21] Tel.: +33-1 44/27 12 22,undefined

[22] Fax: +33-1 44/27 12 60,undefined

[23] E-Mail: christian.giaume@college-de-france.fr,undefined

来源：

European Archives of Psychiatry and Clinical Neuroscience | 2001年 / 251卷

关键词：

Key words Astrocytes; Metabolism; Gap junction; Signaling; Neuron-glia communication;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Astrocytes are the most numerous cell type within the central nervous system. Early during development they act as guiding structures for migratory neurons; later they are not only the main source for nutrients and growth factors in the brain, but they are also communication partners of neighboring neurons. For this purpose astrocytes are equipped with several types of transmitter receptors and the capacity to release neuroactive substances. In addition, they form an extended syncytium via gap junction channels which allows fast intercellular signaling pathways. The pivotal involvement of astrocytes in brain function during disease situations is the topic of many studies.

引用

页码：159 / 169

页数：10

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