The ventro-medial prefrontal cortex: A major link between the autonomic nervous system, regulation of emotion, and stress reactivity?

被引：109
|
作者：
Hänsel A. [1 ]
von Känel R. [1 ]
机构：
[1] Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Berne
来源：
BioPsychoSocial Medicine | / 2卷 / 1期
关键词：
Heart Rate Variability; Major Depressive Disorder; Autonomic Nervous System; Social Anxiety Disorder; Parasympathetic Activity;
D O I：
10.1186/1751-0759-2-21
中图分类号：
学科分类号：
摘要：
Recent progress in neuroscience revealed diverse regions of the CNS which moderate autonomic and affective responses. The ventro-medial prefrontal cortex (vmPFC) plays a key role in these regulations. There is evidence that vmPFC activity is associated with cardiovascular changes during a motor task that are mediated by parasympathetic activity. Moreover, vmPFC activity makes important contributions to regulations of affective and stressful situations. This review selectively summarizes literature in which vmPFC activation was studied in healthy subjects as well as in patients with affective disorders. The reviewed literature suggests that vmPFC activity plays a pivotal role in biopsychosocial processes of disease. Activity in the vmPFC might link affective disorders, stressful environmental conditions, and immune function. © 2008 Haensel and von Kaenel; licensee BioMed Central Ltd.
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