Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

被引：0
|
作者：
C. Bellone
C. Lüscher
M. Mameli
机构：
[1] University of Geneva,Dept. of Basic Neurosciences, Medical Faculty
[2] Geneva University Hospital,Clinic of Neurology, Dept. of Clinical Neurosciences
来源：
Cellular and Molecular Life Sciences | 2008年 / 65卷
关键词：
Long-term depression; synaptic transmission; metabotropic glutamate receptors; AMPA receptors;
D O I：
暂无
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学科分类号：
摘要：
Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
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页码：2913 / 2923
页数：10
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