p16Ink4a overexpression in cancer: a tumor suppressor gene associated with senescence and high-grade tumors

被引：0
|
作者：
C Romagosa
S Simonetti
L López-Vicente
A Mazo
M E Lleonart
J Castellvi
S Ramon y Cajal
机构：
[1] Fundació Institut de Recerca,Pathology Department
[2] Hospital Universitari Vall d’Hebron,Department of Biochemistry and Molecular Biology
[3] Universitat Autònoma de Barcelona,undefined
[4] Pangaea Biotech,undefined
[5] Oncology Laboratory,undefined
[6] USP Dexeus University Institute,undefined
[7] University of Barcelona,undefined
[8] Institute of Biomedicine (IBUB),undefined
来源：
Oncogene | 2011年 / 30卷
关键词：
p16; overexpression; cancer; senescence; high grade;
D O I：
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学科分类号：
摘要：
p16Ink4a is a protein involved in regulation of the cell cycle. Currently, p16Ink4a is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, overexpression of p16Ink4a has also been described in several tumors. This review attempts to elucidate when and why p16Ink4a overexpression occurs, and to suggest possible implications of p16Ink4a in the diagnosis, prognosis and treatment of cancer.
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页码：2087 / 2097
页数：10
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