The dual personality of ionic copper in biology

被引：0
|
作者：
Martine Cuillel
机构：
[1] CEA,
[2] DSV,undefined
[3] iRTSV,undefined
[4] Laboratoire de Chimie et Biologie des Métaux,undefined
[5] CNRS,undefined
[6] UMR 5249,undefined
[7] Université Joseph Fourier,undefined
来源：
Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2009年 / 65卷
关键词：
Copper; Biology; Homeostasis; Toxicity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Biological copper is mainly involved in electron transport to catalyse essential oxido-reduction processes. It is an essential trace element which is extremely toxic because exchangeable intracellular copper is Cu(I) which generates reactive oxygen species. To handle this paradox the evolution has led to a fine homeostasis in which copper ions are never free. Intracellular Cu(I) instead is bound to numerous proteins forming specific cascades towards its targets.
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页码：165 / 170
页数：5
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