Human BRCA1–BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection

被引：0

作者：

Ruth M Densham

Alexander J Garvin

Helen R Stone

Joanna Strachan

Robert A Baldock

Manuel Daza-Martin

Alice Fletcher

Sarah Blair-Reid

James Beesley

Balraj Johal

Laurence H Pearl

Robert Neely

Nicholas H Keep

Felicity Z Watts

Joanna R Morris

机构：

[1] Birmingham Centre for Genome Biology,Department of Biological Sciences

[2] Institute of Cancer and Genomic Sciences,undefined

[3] University of Birmingham,undefined

[4] Genome Damage and Stability Centre,undefined

[5] School of Life Sciences,undefined

[6] University of Sussex,undefined

[7] School of Chemistry,undefined

[8] University of Birmingham,undefined

[9] Institute for Structural and Molecular Biology,undefined

[10] Birkbeck,undefined

[11] University of London,undefined

[12] Present address: Institute of Cell Biology,undefined

[13] University of Edinburgh,undefined

[14] Edinburgh,undefined

[15] UK.,undefined

来源：

Nature Structural & Molecular Biology | 2016年 / 23卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The E3 ubiquitin ligase activity of the BRCA1–BARD1 complex is required to reposition 53BP1 on damaged chromatin and to promote DNA resection and repair via homologous recombination, in a mechanism involving the chromatin remodeler SMARCAD1.

引用

页码：647 / 655

页数：8

共 50 条

[1] Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection
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[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2016, 23 (07) : 647 - 655
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