AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

被引：0
|
作者：
Joungmok Kim
Mondira Kundu
Benoit Viollet
Kun-Liang Guan
机构：
[1] University of California at San Diego,Department of Pharmacology and Moores Cancer Center
[2] St. Jude Children's Hospital,Department of Pathology
[3] INSERM U1016,undefined
[4] Institut Cochin,undefined
[5] Université Paris Descartes,undefined
[6] CNRS (UMR 8104),undefined
来源：
Nature Cell Biology | 2011年 / 13卷
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学科分类号：
摘要：
A molecular mechanism that links the mTOR and autophagy pathways is now revealed. Depending on nutrient availability, the AMPK and mTOR kinases differentially phosphorylate the autophagy-initiating kinase Ulk1 to regulate its activity.
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页码：132 / 141
页数：9
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