Gamma secretase–mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke

被引：0
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作者：
Thiruma V Arumugam
Sic L Chan
Dong-Gyu Jo
Gokhan Yilmaz
Sung-Chun Tang
Aiwu Cheng
Marc Gleichmann
Eitan Okun
Vishwa D Dixit
Srinivasulu Chigurupati
Mohamed R Mughal
Xin Ouyang
Lucio Miele
Tim Magnus
Suresh Poosala
D Neil Granger
Mark P Mattson
机构：
[1] Laboratory of Neurosciences,Department of Molecular & Cellular Physiology
[2] National Institute on Aging Intramural Research Program,Department of Neurology
[3] Louisiana State University Health Sciences Center,Department of Biopharmaceutical Sciences and Cancer Center
[4] Stroke Center,Department of Neuroscience
[5] National Taiwan University Hospital,undefined
[6] Laboratory of Immunology,undefined
[7] National Institute on Aging Intramural Research Program,undefined
[8] Research Resources Branch,undefined
[9] National Institute on Aging Intramural Research Program,undefined
[10] University of Illinois,undefined
[11] Johns Hopkins University School of Medicine,undefined
来源：
Nature Medicine | 2006年 / 12卷
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学科分类号：
摘要：
Mice transgenic for antisense Notch and normal mice treated with inhibitors of the Notch-activating enzyme γ-secretase showed reduced damage to brain cells and improved functional outcome in a model of focal ischemic stroke. Notch endangers neurons by modulating pathways that increase their vulnerability to apoptosis, and by activating microglial cells and stimulating the infiltration of proinflammatory leukocytes. These findings suggest that Notch signaling may be a therapeutic target for treatment of stroke and related neurodegenerative conditions.
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页码：621 / 623
页数：2
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