Twenty single-nucleotide polymorphisms in four genes encoding cardiac ion channels

被引：0
|
作者：
H. Iwasa
M. Kurabayashi
R. Nagai
Y. Nakamura
T. Tanaka
机构：
[1] Laboratory of Molecular Medicine,
[2] Human Genome Center,undefined
[3] Institute of Medical Science,undefined
[4] University of Tokyo,undefined
[5] 4-6-1 Shirokanedai,undefined
[6] Minato-ku,undefined
[7] Tokyo 108-8639,undefined
[8] Japan Tel. +81-3-5449-5375; Fax +81-3-5449-5406 e-mail: toshitan@ims.u-tokyo.ac.jp,undefined
[9] Second Department of Internal Medicine,undefined
[10] Gunma University School of Medicine,undefined
[11] Gunma,undefined
[12] Japan,undefined
[13] Department of Cardiovascular Medicine,undefined
[14] Graduate School of Medicine,undefined
[15] University of Tokyo,undefined
[16] Tokyo,undefined
[17] Japan,undefined
来源：
Journal of Human Genetics | 2002年 / 47卷
关键词：
Key words Long QT syndrome; Single-nucleotide polymorphism; Japanese population; Voltage-gated potassium ion channel; KChIP; L-type voltage-dependent calcium ion channel;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We here report 20 novel single-nucleotide polymorphisms in four genes that are potentially involved in the excitement of cardiomyocytes: 1 in KCNA5 (encoding Kv1.5), 5 in KCNAB1 (encoding Kvβ1.3), 5 in KCNIP2 (encoding KChIP2), and 9 in CACNA1C (encoding a cardiac L-type voltage-dependent calcium ion channel, dihydropyridine receptor). We also examined their allelic frequencies in Japanese individuals. These data will be useful for genetic association studies designed to investigate secondary long QT syndrome or other circulatory disorders.
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页码：208 / 212
页数：4
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