The synthesis of 3-(het)aryl-6,7-dihydro-5H-[1,2,4]-triazolo[3,4-a][2]benzazepines

被引：0
|
作者：
Vladimir А. Glushkov
Dmitry N. Babentsev
Maksim V. Dmitriev
Kseniya А. Stepanova
Anastasiya Yu. Kharintseva
Anastasiya E. Simakhina
机构：
[1] Ural Branch of the Russian Academy of Sciences,Institute of Technical Chemistry
[2] Perm State University,undefined
来源：
Chemistry of Heterocyclic Compounds | 2021年 / 57卷
关键词：
4-aryl-2-methylbutan-2-ols; benz[; ]azepines; hetarenecarboxylic acid hydrazides; methyl thiocyanate; 1,2,4-triazolo-2-benzazepines; Ritter reaction;
D O I：
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学科分类号：
摘要：
4-Aryl-2-methylbutan-2-ols with methoxy or methylenedioxy substituents participate in the Graf–Ritter reaction with methyl thiocyanate in the presence of an acid (H2SO4, MeSO3H) forming 1-methylsulfanyl-2-benzazepines in low yields (11–35%), which undergo cyclization with benzhydrazide or hetarenecarboxylic acid hydrazides upon reflux in o-dichlorobenzene into the corresponding 3-phenyl- and 3-hetaryl-6,7-dihydro-5H-1,2,4-triazolo[3,4-a][2]benzazepines (45–74% yields).
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页码：63 / 68
页数：5
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