Calcium oxalate urolithiasis in children: urinary promoters/inhibitors and role of their ratios

被引:0
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作者
Daniel Turudic
Danica Batinic
Anja Tea Golubic
Mila Lovric
Danko Milosevic
机构
[1] University of Zagreb School of Medicine,Department of Nuclear Medicine
[2] Children’s Hospital Srebrnjak,Department of Clinical Laboratory Diagnostic
[3] University Hospital Center Zagreb,Department of Pediatric Nephrology, Dialysis and Transplantation, University of Zagreb School of Medicine
[4] University Hospital Center Zagreb,undefined
[5] University Hospital Center Zagreb,undefined
来源
European Journal of Pediatrics | 2016年 / 175卷
关键词
Calcium; Oxalate; Citrate; Glycosaminoglycans; Urolithiasis; Children;
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学科分类号
摘要
Diagnostic criteria for determination of inclination towards idiopathic calcium oxalate (CaOx) urolithiasis based on biochemical urine parameters are not sufficiently well defined in children. The aim of this study was to determine the risk of CaOx urolithiasis in children from concentrations of calcium, oxalate, citrate, and glycosaminoglycans in urine and their ratios, all standardized in respect to creatinine. We collected and analyzed 24-h urine samples of children with CaOx urolithiasis (n = 61) and compared with urine samples of matched control group of healthy children (n = 25). The study has showed that all stone formers have higher excretion of calcium (mmol/mmol creatinine), calcium/citrate (mol/mmol), and oxalate/(citrate × glycosaminoglycans) ratio (mol Ox × mol cr)/(mol Cit × g GAGs). ROC analysis of these variables gave criteria (>0.28, >1.07, and >0.08, respectively) for distinguishing stone formers from healthy children. Biochemical urine parameters and their ratios (calcium, calcium citrate, and oxalate/(citrate × glycosaminoglycans) enable one to discriminate idiopathic calcium oxalate stone formers from healthy children. Oxalate/(citrate × glycosaminoglycans) ratio per se can serve as an independent risk for stone formation.
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页码:1959 / 1965
页数:6
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