Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy

被引:0
|
作者
Mengxia Fu
Xiumeng Hua
Songren Shu
Xinjie Xu
Hang Zhang
Zhiming Peng
Han Mo
Yanyun Liu
Xiao Chen
Yicheng Yang
Ningning Zhang
Xiaohu Wang
Zirui Liu
Guangxin Yue
Shengshou Hu
Jiangping Song
机构
[1] Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Centre, Fuwai Hospital, National Center for Cardiovascular Disease
[2] Beijing Shijitan Hospital,Galactophore Department, Galactophore Center
[3] Capital Medical University,State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases
[4] Chinese Academy of Medical Sciences and Peking Union Medical College,Department of Orthopedics
[5] Peking Union Medical College Hospital,Shenzhen Key Laboratory of Cardiovascular Disease
[6] Chinese Academy of Medical Sciences and Peking Union Medical College,Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology
[7] Fuwai Hospital Chinese Academy of Medical Sciences,Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases
[8] Xidian University,The Cardiomyopathy Research Group, Fuwai Hospital, National Center for Cardiovascular Diseases
[9] Chinese Academy of Medical Sciences and Peking Union Medical College,undefined
[10] Chinese Academy of Medical Sciences and Peking Union Medical College,undefined
来源
BMC Medicine | / 22卷
关键词
Arrhythmogenic right ventricular cardiomyopathy; Single-cell RNA sequencing; NLRP3;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 42 条
  • [1] Single-cell RNA sequencing in donor and end-stage heart failure patients identifies NLRP3 as a therapeutic target for arrhythmogenic right ventricular cardiomyopathy
    Fu, Mengxia
    Hua, Xiumeng
    Shu, Songren
    Xu, Xinjie
    Zhang, Hang
    Peng, Zhiming
    Mo, Han
    Liu, Yanyun
    Chen, Xiao
    Yang, Yicheng
    Zhang, Ningning
    Wang, Xiaohu
    Liu, Zirui
    Yue, Guangxin
    Hu, Shengshou
    Song, Jiangping
    BMC MEDICINE, 2024, 22 (01)
  • [2] Clinical course of arrhythmogenic right ventricular cardiomyopathy with end-stage heart failure and outcome after heart transplantation
    Petruescu, Laura
    Lebreton, Guillaume
    Coutance, Guillaume
    Maupain, Carole
    Fressart, Veronique
    Badenco, Nicolas
    Waintraub, Xavier
    Duthoit, Guillaume
    Laredo, Mikael
    Himbert, Caroline
    Hidden-Lucet, Francoise
    Leprince, Pascal
    Varnous, Shaida
    Gandjbakhch, Estelle
    ARCHIVES OF CARDIOVASCULAR DISEASES, 2023, 116 (01) : 9 - 17
  • [3] Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies SPP1+ Macrophage Subpopulation as a Target for Alleviating Fibrosis
    Fu, Mengxia
    Shu, Songren
    Peng, Zhiming
    Liu, Xiaorui
    Chen, Xiao
    Zeng, Zhiwei
    Yang, Yicheng
    Cui, Hao
    Zhao, Ruojin
    Wang, Xiaohu
    Du, Leilei
    Wu, Min
    Feng, Wei
    Song, Jiangping
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2023, 43 (11) : 2143 - 2164
  • [4] Combination of therapeutic apheresis and therapeutic ventricular assistance for end-stage heart failure patients
    Schulte-Eistrup, S
    Ashizawa, S
    Nonaka, K
    Ichikawa, S
    Motomura, T
    Murai, N
    Nosé, Y
    THERAPEUTIC APHERESIS, 2002, 6 (04): : 247 - 254
  • [5] Model for End-Stage Liver Disease (MELD) Stratification Identifies Two Distinct Cohorts of Arrhythmogenic Right Ventricular Cardiomyopathy Patients Undergoing Transplantation
    Reza, N.
    Mahmud, N.
    Molina, M.
    McLean, R.
    Goldberg, L. R.
    Acker, M. A.
    Bermudez, C.
    Owens, A.
    JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2018, 37 (04): : S335 - S335
  • [6] Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
    Simonson, Bridget
    Chaffin, Mark
    Hill, Matthew C.
    Atwa, Ondine
    Guedira, Yasmine
    Bhasin, Harshit
    Hall, Amelia W.
    Hayat, Sikander
    Baumgart, Simon
    Bedi, Kenneth C.
    Margulies, Kenneth B.
    Klattenhoff, Carla A.
    Ellinor, Patrick T.
    CELL REPORTS, 2023, 42 (02):
  • [7] Left ventricular noncompaction cardiomyopathy in end-stage heart failure patients undergoing orthotopic heart transplantation
    Ottaviani, Giulia
    Segura, Ana Maria
    Rajapreyar, Indranee N.
    Zhao, Bihong
    Radovancevic, Rajko
    Loyalka, Pranav
    Kar, Biswajit
    Gregoric, Igor
    Buja, L. Maximilian
    CARDIOVASCULAR PATHOLOGY, 2016, 25 (04) : 293 - 299
  • [8] Defining cardiac functional recovery in end-stage heart failure at single-cell resolution
    Amrute, Junedh M.
    Lai, Lulu
    Ma, Pan
    Koenig, Andrew L.
    Kamimoto, Kenji
    Bredemeyer, Andrea
    Shankar, Thirupura S.
    Kuppe, Christoph
    Kadyrov, Farid F.
    Schulte, Linda J.
    Stoutenburg, Dylan
    Kopecky, Benjamin J.
    Navankasattusas, Sutip
    Visker, Joseph
    Morris, Samantha A.
    Kramann, Rafael
    Leuschner, Florian
    Mann, Douglas L.
    Drakos, Stavros G.
    Lavine, Kory J.
    NATURE CARDIOVASCULAR RESEARCH, 2023, 2 (04): : 399 - +
  • [9] Defining cardiac functional recovery in end-stage heart failure at single-cell resolution
    Junedh M. Amrute
    Lulu Lai
    Pan Ma
    Andrew L. Koenig
    Kenji Kamimoto
    Andrea Bredemeyer
    Thirupura S. Shankar
    Christoph Kuppe
    Farid F. Kadyrov
    Linda J. Schulte
    Dylan Stoutenburg
    Benjamin J. Kopecky
    Sutip Navankasattusas
    Joseph Visker
    Samantha A. Morris
    Rafael Kramann
    Florian Leuschner
    Douglas L. Mann
    Stavros G. Drakos
    Kory J. Lavine
    Nature Cardiovascular Research, 2023, 2 : 399 - 416
  • [10] Right ventricular longitudinal deformation correlates closely with right ventricular myocardial fibrosis in patients with end-stage heart failure
    Lisi, M.
    Cameli, M.
    Righini, F. M.
    Malandrino, A.
    Tacchini, D.
    Focardi, M.
    Tsioulpas, C.
    Bernazzali, S.
    Henein, M. Y.
    Mondillo, S.
    EUROPEAN HEART JOURNAL, 2013, 34 : 780 - 780