Histone gene editing probes functions of H3K27 modifications in mammals

被引：0
|
作者：
Alessandro Scacchetti
Roberto Bonasio
机构：
[1] University of Pennsylvania Perelman School of Medicine,Epigenetics Institute, Department of Cell and Developmental Biology
来源：
Nature Genetics | 2022年 / 54卷
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摘要：
A new study employs CRISPR–Cas9-based base editing for simultaneous mutagenesis of all copies of histone H3 genes in mammals, highlighting the functional importance of H3K27me3 for Polycomb-mediated gene silencing and the dispensability of H3K27ac in transcriptional activation.
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页码：746 / 747
页数：1
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