Synthesis of neoglycolipids for the development of non-viral gene delivery systems

被引：0
|
作者：
E. V. Shmendel’
M. A. Maslov
N. G. Morozova
G. A. Serebrennikova
机构：
[1] M. V. Lomonosov Moscow State Academy of Fine Chemical Tehnology,
来源：
Russian Chemical Bulletin | 2010年 / 59卷
关键词：
neoglycolipids; galactose; targeting ligand; 3,4-diethoxycyclobut-3-ene-1,2-dione (diethyl squarate); hepatocytes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Synthesis of lipid conjugates with galactose as a targeting ligand intended for the development of non-viral systems for the targeted delivery of nucleic acids into hepatocytes is described. 3,4-Diethoxycyclobut-3-ene-1,2-dione (diethyl squarate) was used to bind the galactose moiety to the lipid component.
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页码：2281 / 2289
页数：8
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