Proteomic Characteristics of Blood Serum in Rats with Different Behavioral Parameters after Acute Stress

被引：0
|
作者：
N. V. Kirbaeva
N. E. Sharanova
A. V. Vasil’ev
S. S. Pertsov
机构：
[1] Research Institute of Nutrition,
[2] P. K. Anokhin Research Institute of Normal Physiology,undefined
[3] A. E. Evdokimov Moscow State University of Medicine and Density,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 162卷
关键词：
proteomics; blood; immobilization stress; behaviorally passive and active rats;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied proteome profile of blood serum of Wistar rats with different behavioral activity immediately and in 1 and 3 days after acute stress on the model of 12-h immobilization during the nighttime. Comparative analysis of 2D-electrophoretograms revealed differences in the expression of serum proteins in non-stressed (control) and stressed (experimental) rats. We found 22 protein spots that characterized the proteomic features of blood serum in rats with different prognostic resistance to stress. Mass-spectrometry of isolated spots identified 6 functional proteins. Persistent proteome changes in the blood of animals at different stages after acute stress were determined. The specificity of proteomic characteristics of blood serum was shown in behaviorally passive and active rats during the post-stress period. These data extend the concept on specific protein markers for the formation of a negative emotional state and adaptive-and-compensatory processes in mammals with different sensitivity to stressogenic factors.
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页码：602 / 605
页数：3
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