Spindle-cell osteosclerotic bone lesion with MDM2 amplification

被引：0
|
作者：
Mogler, C. [1 ]
Boxberg, M. [1 ]
Knebel, C. [2 ]
Weichert, W. [1 ]
Woertler, K. [3 ]
Specht, K. [1 ]
机构：
[1] Tech Univ Munich, Inst Pathol, Trogerstr 18, D-81675 Munich, Germany
[2] Klinikum Rechts Der Isar, Klin & Poliklin Orthopadie & Sportorthopadie, Munich, Germany
[3] Klinikum Rechts Der Isar, Inst Radiol, Munich, Germany
来源：
PATHOLOGE | 2018年 / 39卷 / 02期
关键词：
Bone neoplasms; Carcinoma; Gene amplification; Stomach neoplasm; Tumor biomarker; GASTRIC CARCINOMAS; OSTEOSARCOMA; EXPRESSION; PAROSTEAL; TUMORS;
D O I：
10.1007/s00292-017-0394-6
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
This case report presents an osteosclerotic bone lesion in a 49-year-old man with MDM2 amplification. The final diagnosis shows metastasis to the bones from stomach cancer. In primary bone tumours, the MDM2 amplifications observed have been described for many other tumour entities as well, and therefore do not exclude bone metastasis from a carcinoma.
引用
收藏
页码：186 / 189
页数：4
相关论文
共 50 条
  • [1] A cutaneous spindle-cell lesion
    Carlson, JA
    Ackernan, AB
    Fletcher, CDM
    Zelger, B
    [J]. AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2001, 23 (01) : 62 - 66
  • [2] AMPLIFICATION OF THE MDM2 GENE IN HUMAN BONE SARCOMAS
    LADANYI, M
    JHANWAR, SC
    TEREK, R
    LATRES, E
    CORDONCARDO, C
    HUVOS, AG
    HEALEY, J
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1993, 53 (03) : 317 - 317
  • [3] MDM2 gene amplification as a predictive biomarker for the MDM2 inhibitor milademetan
    Tirunagaru, Vijaya G.
    Gounder, Mrinal M.
    Kumar, Prasanna R.
    Hong, David S.
    Doebele, Robert C.
    [J]. MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
  • [4] Amplification of MDM2 and MDM4 in Osteosarcoma
    Duhamel, L.
    Ye, H.
    Halai, D.
    Idowu, B.
    Presneau, N.
    Flanagan, A.
    [J]. JOURNAL OF PATHOLOGY, 2010, 222 : S11 - S11
  • [5] Cardiac Sarcoma With MDM2 Amplification
    Neuville, Agnes
    Coindre, Jean-Michel
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2014, 38 (10) : 1449 - 1449
  • [6] The MDM2 gene amplification database
    Momand, J
    Jung, D
    Wilczynski, S
    Niland, J
    [J]. NUCLEIC ACIDS RESEARCH, 1998, 26 (15) : 3453 - 3459
  • [7] MALIGNANT BONE TUMORS - SPINDLE-CELL SARCOMAS
    ROSEN, G
    [J]. PEDIATRIC ANNALS, 1978, 7 (08): : 8 - &
  • [8] ANALYSIS OF GLIOMA CELL-LINES FOR AMPLIFICATION AND OVEREXPRESSION OF MDM2
    HE, J
    REIFENBERGER, G
    LIU, L
    COLLINS, VP
    JAMES, CD
    [J]. GENES CHROMOSOMES & CANCER, 1994, 11 (02): : 91 - 96
  • [9] MDM2 amplification and immunohistochemical expression in sarcomatoid renal cell carcinoma
    Suster, David
    Ronen, Shira
    Peterson, Jess F.
    Mackinnon, Alexander C.
    Hes, Ondrej
    Suster, Saul
    Lin, Douglas I.
    [J]. HUMAN PATHOLOGY, 2019, 87 : 28 - 36
  • [10] Case presentation: sarcomatoid renal cell carcinoma with MDM2 amplification
    Cugura, T.
    Jeruc, J.
    [J]. VIRCHOWS ARCHIV, 2019, 475 : S367 - S367
12345