Racial and ethnic disparities in a real-world precision oncology data registry

被引：0

作者：

Alexander T. M. Cheung

Elina L. Palapattu

Isabella R. Pompa

Christopher M. Aldrighetti

Andrzej Niemierko

Henning Willers

Franklin Huang

Neha Vapiwala

Eliezer Van Allen

Sophia C. Kamran

机构：

[1] NYU Grossman School of Medicine,Department of Radiation Oncology, Massachusetts General Hospital

[2] Broad Institute of Harvard and MIT,Division of Hematology/Oncology, Department of Medicine

[3] Dana-Farber Cancer Institute,Department of Radiation Oncology

[4] Harvard Medical School,undefined

[5] University of California,undefined

[6] San Francisco,undefined

[7] Hospital of the University of Pennsylvania,undefined

[8] Perelman School of Medicine,undefined

来源：

npj Precision Oncology | / 7卷

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摘要：

Biorepositories enable precision oncology research by sharing clinically annotated genomic data, but it remains unknown whether these data registries reflect the true distribution of cancers in racial and ethnic minorities. Our analysis of Project Genomics Evidence Neoplasia Information Exchange (GENIE), a real-world cancer data registry designed to accelerate precision oncology discovery, indicates that minorities do not have sufficient representation, which may impact the validity of studies directly comparing mutational profiles between racial/ethnic groups and limit generalizability of biomarker discoveries to all populations.

引用

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