Synthesis and antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides

被引：0
|
作者：
Zimenkovskii B.S. [1 ]
Kutsyk R.V. [2 ]
Lesyk R.B. [1 ]
Matyichuk V.S. [3 ]
Obushak N.D. [3 ]
Klyufinska T.I. [2 ]
机构：
[1] Lviv National Medical University, Lviv
[2] Ivano-Frankivsk State Medical Academy, Ivano-Frankivsk
[3] Lviv National University, Lviv
来源：
Pharmaceutical Chemistry Journal | 2006年 / 40卷 / 6期
关键词：
Thiazole; Acetamide; Maleic Anhydride; Acid Amide; Thionyl Chloride;
D O I：
10.1007/s11094-006-0115-6
中图分类号：
学科分类号：
摘要：
The antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides and their 3-substituted analogs has been studied. The initial acid was obtained by an effective one-pot method using the reaction of thiourea with maleic anhydride in hydrochloric acid. The maximum anti-staphylococcal activity was exhibited by N-[5-(R-benzyl)thiazol-2-yl]-2-(2,4-dioxothiazolidin-5-yl) acetamides. © 2006 Springer Science+Business Media, Inc.
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页码：303 / 306
页数：3
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