Break-induced replication sparks CGG-repeat instability

被引：0
|
作者：
Madhura Deshpande
Jeannine Gerhardt
机构：
[1] Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine,Department of Obstetrics and Gynecology
[2] Weill Cornell Medicine,undefined
[3] Weill Cornell Medicine,undefined
来源：
Nature Structural & Molecular Biology | 2018年 / 25卷
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摘要：
The mechanism underlying CCG-repeat expansions in patients with fragile X premutation is not well understood. Using a new experimental system in mammalian cells, a study in this issue reports that break-induced replication has a role in CGG-repeat instability.
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页码：643 / 644
页数：1
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