The promise of co-stimulatory blockade in transplantation

被引：0
|
作者：
Rolf N. Barth
Jonathan S. Bromberg
机构：
[1] University of Maryland School of Medicine,Division of Transplantation
来源：
Nature Reviews Nephrology | 2013年 / 9卷
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摘要：
A new study by Lo et al. presents a novel immunosuppressive combination in a clinically relevant primate model of renal allografting. Using belatacept, a fusion protein that inhibits CD28–CD80/CD86 co-stimulation, plus the mammalian target of rapamycin inhibitor sirolimus, they were able to achieve rejection-free allograft survival without the induction of memory T cells or alloantibody.
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页码：189 / 190
页数：1
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