The development of PARP inhibitors in ovarian cancer: from bench to bedside

被引：0
|
作者：
Yvette Drew
机构：
[1] Northern Institute for Cancer Research,
[2] Newcastle University,undefined
[3] Northern Centre for Cancer Care,undefined
[4] Freeman Hospital,undefined
来源：
British Journal of Cancer | 2015年 / 113卷
关键词：
olaparib; PARP; ovarian cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The nuclear enzyme poly (ADP-ribose) polymerase (PARP) represents an important novel target in the treatment of ovarian cancer. This article charts over 50 years of research from the discovery of the first PARP enzyme in 1963, to the approval and licensing in 2015 of the first PARP inhibitor, olaparib (Lynparza), in the treatment of BRCA-mutated ovarian cancer.
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页码：S3 / S9
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