Unbiased morphological measurements show no neuronal loss in the substantia nigra in Alzheimer's disease

被引：0

作者：

N. Kemppainen

M. Röyttä

Y. Collan

S. Ma

S. Hinkka

J. Rinne

机构：

[1] Department of Neurology,

[2] University of Turku,undefined

[3] 20520 Turku,undefined

[4] Finland,undefined

[5] Department of Pathology,undefined

[6] University of Turku,undefined

[7] Turku,undefined

[8] Finland,undefined

[9] Department of Biostatistics,undefined

[10] University of Turku,undefined

[11] Turku,undefined

[12] Finland,undefined

[13] Turku PET Center,undefined

[14] University of Turku,undefined

[15] Turku,undefined

[16] Finland,undefined

来源：

Acta Neuropathologica | 2002年 / 103卷

关键词：

Alzheimer's disease Disector Extrapyramidal symptoms Substantia nigra;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This is the first study to use the unbiased stereological method, the disector, to estimate the total number of pigmented neurons in the pars compacta of the substantia nigra (SNpc) in Alzheimer's disease (AD) patients as compared to healthy controls. The right half of the SNpc of 11 AD patients and 24 controls was studied. We also used single sections to determine the neuronal number and area in different subregions of the SNpc. The results showed that there was no significant difference in the total number of pigmented neurons in the SNpc (154415±13593 for AD and 160163±8027 for controls) or in the volume of the SNpc between the patients with AD and controls. Studies on single sections revealed that even subregionally there was no significant difference in the neuronal number or area in the SNpc between AD patients and controls.

引用

页码：43 / 47

页数：4

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