Convergent transcription induces transcriptional gene silencing in fission yeast and mammalian cells

被引：0
|
作者：
Monika Gullerova
Nick J Proudfoot
机构：
[1] Sir William Dunn School of Pathology,
[2] University of Oxford,undefined
来源：
Nature Structural & Molecular Biology | 2012年 / 19卷
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摘要：
Previous studies have shown the potential for convergent transcription as a way to induce gene silencing. This Technical Report now demonstrates that introducing convergent transcription plasmids into either fission yeast or mammalian cells can be used to mediate long-term transcriptional gene silencing of endogenous genes, with major advantages over other gene silencing strategies.
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页码：1193 / 1201
页数：8
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