A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML

被引：0
|
作者：
Wenxin Du
Zhimei Xia
Zebin Luo
Yichang Chen
Shaowei Bing
Wei Wang
Xingya Zhang
Zhan Zhou
Jingying Zhang
Ji Cao
Bo Yang
Qiaojun He
Xuejing Shao
Xiaojun Xu
Meidan Ying
机构：
[1] Zhejiang University,Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti
[2] Children’s Hospital,Cancer Drug Research, College of Pharmaceutical Sciences
[3] Zhejiang University School of Medicine,Division of Hematology
[4] National Clinical Research Center for Child Health,Oncology
[5] College of Pharmaceutical Sciences and Alibaba-Zhejiang University Joint Research Center of Future Digital Healthcare,Innovation Institute for Artificial Intelligence in Medicine, Zhejiang Provincial Key Laboratory of Anti
[6] Zhejiang University,Cancer Drug Research
[7] Ministry of Education,Engineering Research Center of Innovative Anticancer Drugs
[8] Zhejiang University,Cancer Center
来源：
Leukemia | 2023年 / 37卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：2286 / 2291
页数：5
相关论文
共 38 条
  • [1] A novel gene fusion RUNX1/ZNF423 promotes leukemic relapse of NUP98-rearranged AML
    Du, Wenxin
    Xia, Zhimei
    Luo, Zebin
    Chen, Yichang
    Bing, Shaowei
    Wang, Wei
    Zhang, Xingya
    Zhou, Zhan
    Zhang, Jingying
    Cao, Ji
    Yang, Bo
    He, Qiaojun
    Shao, Xuejing
    Xu, Xiaojun
    Ying, Meidan
    LEUKEMIA, 2023, 37 (11) : 2286 - 2291
  • [2] The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML
    Heikamp, Emily B.
    Henrich, Jill A.
    Perner, Florian
    Wong, Eric M.
    Hatton, Charles
    Wen, Yanhe
    Barwe, Sonali P.
    Gopalakrishnapillai, Anilkumar
    Xu, Haiming
    Uckelmann, Hannah J.
    Takao, Sumiko
    Kazansky, Yaniv
    Pikman, Yana
    McGeehan, Gerard M.
    Kolb, Edward A.
    Kentsis, Alex
    Armstrong, Scott A.
    BLOOD, 2022, 139 (06) : 894 - 906
  • [3] AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms
    Ding, Ye
    Harada, Yuka
    Imagawa, Jun
    Kimura, Akiro
    Harada, Hironori
    BLOOD, 2009, 114 (25) : 5201 - 5205
  • [4] AML1/RUNX1 Point Mutation Possibly Promotes Leukemic Transformation in Myeloproliferative Disorders
    Imagawa, Jun
    Harada, Yuka
    Ding, Ye
    Kimura, Akiro
    Harada, Hironori
    BLOOD, 2009, 114 (22) : 755 - 755
  • [5] Epigenetic Resistance to Menin-MLL1 Inhibition Is Driven By Loss of the Non-Canonical Polycomb Repressive Complex 1.1 in NUP98-Rearranged AML
    Heikamp, Emily B.
    Henrich, Jill A.
    Rice, Hannah E.
    Mahendra-Rajah, Sanisha
    Armstrong, Scott A.
    BLOOD, 2022, 140
  • [6] NUP98-NSD1 GENE FUSION IS A STRONG POOR PROGNOSTIC FACTOR IN PEDIATRIC AML
    Hara, Y.
    Shiba, N.
    Shimada, A.
    Kudo, K.
    Tomizawa, D.
    Taga, T.
    Horibe, K.
    Adachi, S.
    Arakawa, H.
    Tawa, A.
    Hayashi, Y.
    PEDIATRIC BLOOD & CANCER, 2013, 60 : 5 - 6
  • [7] Targeting Quiescent Leukemic Stem Cells and Overcoming Therapy Resistance in NUP98-NSD1 Fusion-Positive AML
    Wang, Ke
    Saniei, Shayan
    Poddar, Nikita
    Persaud, Subrina
    Sreenath, Meghana
    Quijada-alamo, Miguel
    Freed, Grace
    Mei, Anna Huo Chang
    Rahman, Noshin
    Chipuk, Jerry
    Wagenblast, Elvin
    BLOOD, 2024, 144 : 1340 - 1341
  • [8] COMPLEX AMPLIFICATION OF CHROMOSOME 21 MASKING A NOVEL CRYPTIC RUNX1 GENE FUSION IN AN AML CELL LINE (OCI-M2)
    Chen, S.
    Schneider, B.
    Nagel, S.
    Geffers, R.
    Quentmeier, H.
    Kaufmann, M.
    Drexler, H.
    MacLeod, R.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 202 - 202
  • [9] A NUP98-NSD1 Fusion Gene Can Be Detected in a Small Subset of Adult AML Patients with Normal Karyotype
    Fasan, Annette
    Haferlach, Claudia
    Alpermann, Tamara
    Kern, Wolfgang
    Haferlach, Torsten
    Schnittger, Susanne
    BLOOD, 2011, 118 (21) : 1085 - 1086
  • [10] A novel pedigree with heterozygous germline RUNX1 mutation causing familial MDS related AML - Can these families serve as a multistep model for leukemic transformation in MDS and AML?
    Steinemann, D.
    Ripperger, T.
    Goehring, G.
    Niemeyer, C.
    Strahm, B.
    Schlegelberger, B.
    CHROMOSOME RESEARCH, 2009, 17 : 150 - 150
1234