Pineamin Increases Melatonin Synthesis in Pineal Gland of Elderly People

被引：3
|
作者：
Trofimova S.V. [1 ]
Linkova N.S. [1 ,2 ]
Klimenko A.A. [3 ]
Kvetnaia T.V. [1 ]
Khavinson V.K. [1 ,4 ]
机构：
[1] St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg
[2] Peter the Great St. Petersburg Technical University, St. Petersburg
[3] Geropharm Group of Companies, St. Petersburg
[4] Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg
来源：
Advances in Gerontology | 2017年 / 7卷 / 4期
关键词：
6-sulfatoxymelatonin; aging; pineal gland; Pineamin;
D O I：
10.1134/S2079057017040130
中图分类号：
学科分类号：
摘要：
The effect of a pineal gland polypeptide complex, Pineamin, on urine excretion of 6-sulfatoxymelatonin (6-SOMT) was investigated by immunoenzyme assay in 55 elderly patients with decreased melatonin formation. Pineamin at a dose of 100 mg increased the level of 6-SOMT excretion in overnight urine by 1.9 times in comparison with the respective indicator before the treatment. A similar effect was previously obtained upon the administration of Epitalamin, which also facilitated the restoration of melatonin synthesis in human and animal pineal glands affected by aging. Hence, Pineamin and Epitalamin exhibit a one-directional stimulating property with respect to the melatonin-forming function of the pineal gland in elderly people. © 2017, Pleiades Publishing, Ltd.
引用
收藏
页码：319 / 322
页数：3
相关论文
共 50 条
  • [1] Melatonin synthesis in the human pineal gland
    Katrin Ackermann
    Roman Bux
    Udo Rüb
    Gerold Kauert
    Jörg H Stehle
    BMC Neuroscience, 8 (Suppl 1)
  • [2] Lipoxygenation and melatonin synthesis in rat pineal gland
    Zhang, H
    Kim, HY
    FASEB JOURNAL, 1996, 10 (03): : 2384 - 2384
  • [3] MELATONIN SYNTHESIS IN PINEAL GLAND - CONTROL BY LIGHT
    WURTMAN, RJ
    AXELROD, J
    PHILLIPS, LS
    SCIENCE, 1963, 142 (359) : 1071 - &
  • [4] Melatonin in the pineal gland
    Steinlechner, S
    JOURNAL OF NEUROCHEMISTRY, 1996, 66 : S57 - S57
  • [5] PINEAL GLAND MELATONIN SYNTHESIS AND TESTICULAR DEVELOPMENT IN RAT
    TAIT, GR
    BARFUSS, DW
    ELLIS, LC
    LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1969, 8 (13P1): : 717 - &
  • [6] INDOLPYRUVIC ACID INCREASES PINEAL MELATONIN SYNTHESIS IN RATS
    FERRETTI, C
    BLENGIO, M
    GHI, P
    POLITI, V
    GENAZZANI, E
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (02) : 291 - 291
  • [7] MELATONIN AND THE PINEAL-GLAND
    TOUITOU, Y
    PATHOLOGIE BIOLOGIE, 1994, 42 (04): : 277 - 278
  • [8] PINEAL-GLAND AND MELATONIN
    MASUZAWA, T
    TANAKA, H
    KUROKAWA, N
    YAMADA, N
    NEUROLOGICAL SURGERY, 1995, 23 (10): : 857 - 868
  • [9] Melatonin synthesis in the human pineal gland: Advantages, implications, and difficulties
    Ackermann, K
    Stehle, JH
    CHRONOBIOLOGY INTERNATIONAL, 2006, 23 (1-2) : 369 - 379
  • [10] SYNTHESIS AND RELEASE OF MELATONIN FROM RAT PINEAL-GLAND
    TSUI, HW
    BROWN, GM
    GROTA, LJ
    CLINICAL RESEARCH, 1978, 26 (06): : A848 - A848
12345